. Author manuscript; available in PMC: 2014 Aug 19.

Published in final edited form as: J Hum Hypertens. 2014 Feb 13;28(9):551–556. doi: 10.1038/jhh.2013.149

Table 5.

Haplotype analyses of the LEPR gene polymorphisms in hypertension and control subjects

		Haplotype frequency
Lys109Arg	Gln223Arg	Cases	Controls	HS test P-value^a	OR (95% CI)^a	P-value^b	OR (95% CI)^b
G	G	0.808	0.784	0.132	1.162 (0.956–1.413)	–	–
A	A	0.114	0.120	0.647	0.944(0.738–1.207)	0.519	1.085 (0.847–1.390)
A	G	0.065	0.069	0.0690	0.931 (0.679–1.278)	0.550	1.102 (0.802–1.514)
G	A	0.014	0.028	0.012	0.482 (0.273-0.850)	0.010	0.474 (0.269–0.837)

Abbreviations: CI, confidence interval; HS test, haplotype-specific testing; OR, odds ratio. All haplotypes with frequency >1% detected in the haplotype analyses are shown in the table.

P-values and OR values derived from comparing of a specific haplotype with the other three.

P-values and OR values derived from comparing each haplotype with the baseline haplotype (G-G). P-values <0.05 are provided in bold to emphasize their significance.