Table 1.

Selected transgenic mouse models expressing HCV proteins and liver pathology.

Transgene and promoter		Liver phenotype	Reference
Core	HBV	Steatosis	Perlemuter et al. 2002 [25]
		HCC	Moriya et al. 1998 [29]
		Oxidative stress	Moriya et al. 2001 [30]
		Alteration of cytokine expression	Tsutsumi et al. 2002 [41]
		Activation of retinoid X receptor alpha	Tsutsumi et al. 2002 [46]
		Steatosis, HCC	Moriishi et al. 2007 [26]
			Tanaka et al. 2008 [49]
			Tanaka et al. 2008 [50]
	EF-1α	Oxidative stress	Machida et al. 2006 [53]
Core-E1-E2	Albumin	Steatosis, HCC	Lerat et al. 2002 [32]
		HCC	Kamegaya et al. 2005 [34]
		Oxidative stress	Okuda et al. 2002 [54]
			Korenaga et al. 2005 [55]
	CMV	Steatosis, HCC	Naas et al. 2005 [92]
Core-E1-E2-NS2	Cre-loxP system	Hepatitis, Cellular immune responses	Wakita et al. 1998 [61]
			Wakita et al. 2000 [62]
		Suppression of Fas-mediated cell death	Machida et al. 2001 [63]
Polyprotein	Alpha1 antitrypsin	Steatosis, intrahepatic	Alonzi et al. 2004 [93]
		T cell recruitment
	Albumin	Steatosis, HCC	Lerat et al. 2002 [32]
		Impairment of cellular immune response	Disson et al. 2004 [59]