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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Virology. 2014 Feb 25;0:78–92. doi: 10.1016/j.virol.2014.01.030

Figure 2. Increased survival of GX−/− vs. GX+/− or GX+/+ mice following A/Mexico/4108/2009 infection.

Figure 2

GX+/+ (n = 25), GX+/− (n = 32), and GX−/− (n = 24) mice (C57BL/6J background, lacks GIIA-sPLA2) were infected intranasally with A/Mexico/4108/2009 and survival was assessed for a 14 day period (A). GX+/+ (n = 71) and GX−/− (n = 57) mice (C3H/HeN background, expresses GIIA-sPLA2) were infected intranasally with A/Mexico/4108/2009 and survival was assessed for a 14 day period (B). Animals were sacrificed if their body weight decreased to less than 80% of baseline weight, or if the 14-day duration of the study was completed. Log rank test, p < 0.05 GX−/− vs. GX+/+ and GX+/− mice or p < 0.05, GX−/− vs. GX+/+ mice. All the mice used in these experiments were genotyped littermates and grouped and analyzed by their genotype (Reviewer 1 Comment 3).