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. Author manuscript; available in PMC: 2008 Nov 28.
Published in final edited form as: J Neurosci. 2008 May 28;28(22):5762–5771. doi: 10.1523/JNEUROSCI.0575-08.2008

Figure 4.

Figure 4

Effects of CGP 55845A (CGP) and baclofen on IPSC amplitude in CeA. A: I-O curve from CeA neurons of naïve and ethanol-dependent rats. CGP 55845A (1 μM) in the presence of APV and CNQX significantly (p < 0.05, n = 13) increases mean IPSC sizes (averaged over all stimulus intensities) in naive animals. B: Time-course of mean IPSCs evoked by half maximal stimulus intensity recorded from CeA neurons from naïve (n = 7) and ethanol-dependent (n = 5) rats. C: CGP 55845A also significantly (*p < 0.05) decreased the mean PPF of IPSCs but only in CeA from naïve rats. D: The GABAB receptor agonist baclofen (10 μM) is less effective in CeA neurons taken from CET rats compared to naïve rats. Superfusion of baclofen for 10 min markedly (p < 0.001) decreased the GABA-IPSC amplitudes in neurons from naïve rats. In neurons from CET rats the effects of baclofen were significantly (p < 0.05) reduced, suggesting a decrease in GABAB receptor sensitivity after CET. E: Representative traces of a paired-pulse study (at 50 msec interstimulus intervals) of IPSCs in CeA neuron from naive (top) and CET (right) rats (bottom). F: Pooled data of mean PPF ratios in neurons of naïve and CET rats. Baclofen significantly (*p < 0.05) increased PPF ratio of IPSCs in naive (n = 7) rats but not in CET (n = 6) rats.