Table 1.
Time spent ± SEM in the open and closed arms of the elevated plus-maze and closed arm entries ± SEM by rats injected i.p. with one of two doses (0.0, 3.0 g/kg) of 10% w/v ethanol. The plus-maze test was administered 10 hours following ethanol injection, and 30 minutes following i.p. injection with one of four gabapentin doses (0, 30, 60, 120 mg/kg). The plus-maze test lasted 300 seconds in total duration.
Ethanol Dose | Gabapentin Dose | n | Time spent in open arms (sec) | Time spent in closed arms (sec) | Closed arm entries |
---|---|---|---|---|---|
0.0 g/kg | |||||
0 mg/kg | 8 | 35.70 ± 12.02 | 101.30 ± 18.26 | 26.00 ± 3.78 | |
30 mg/kg | 7 | 42.60 ± 9.51 | 112.90 ± 7.61 | 23.71 ± 1.95 | |
60 mg/kg | 8 | 54.75 ± 12.77 | 126.38 ± 5.53 | 23.13 ± 3.07 | |
120 mg/kg | 8 | 29.00 ± 12.47 | 148.75 ± 6.44 | 19.88 ± 8.46 | |
3.0 g/kg * | |||||
0 mg/kg | 8 | 14.10 ± 6.39 | 189.00 ± 20.39 | 19.75 ± 3.85 | |
30 mg/kg | 7 | 24.30 ± 10.97 | 148.80 ± 34.33 | 20.14 ± 2.68 | |
60 mg/kg | 8 | 31.38 ± 11.45 | 164.63 ± 25.46 | 9.63 ± 2.35 | |
120 mg/kg | 8 | 43.00 ± 16.54 | 130.00 ± 27.53 | 13.25 ± 4.86 |
p<0.05 significant main effect of ethanol on closed arm entries.