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Schematic diagram of sequence of events involved in HIV Env mediated fusion. Binding of gp120 to receptor and coreceptor induces conformational changes that allow the exposure of gp41 Heptad Repeat (HR) regions. Interaction of HR1 and HR2 regions of gp41 results in six helix bundle formation resulting in fusion. The binding of CXCR4 antagonist AMD3100 and gp41 fusion inhibitors T20 and C34 are also shown.
