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. Author manuscript; available in PMC: 2008 Sep 8.
Published in final edited form as: J Biol Chem. 2008 Mar 17;283(20):14132–14143. doi: 10.1074/jbc.M708034200

FIGURE 2. PAK translocation in Tg2576 mice.

FIGURE 2

A, immunofluorescent staining of PAK translocation in hippocampus of Tg2576 mice. 22-Month-old Tg2576 transgenic Tg• and control Tg• mice were stained with anti-pPAK antibody. Anti-pPAK identified a loss of diffuse perikaryal and dendritic labeling along with granular structures in Tg2576 transgenic Tg• mice; scale bar, 25 • m. B–D, Western immunoblot analysis of PAK translocation in the cortex in aged Tg2576 mice. The levels of pPAK were significantly reduced in membrane and cytosol from Tg2576 Tg• mice when compared with control Tg2576 Tg• mice (B, *, p • 0.05; C, ***; p • 0.001), and in contrast, the pPAK ratio of membrane to cytosol was significantly increased in Tg2576 Tg• mice when compared with control Tg2576 Tg• mice (D, ***, p • 0.001).

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