Table 3.
FKA mg/kg | QR (nmol DCP-IP reduced/min/mg protein)
|
||||
---|---|---|---|---|---|
0 | 3 | 7 | 15 (days of administration) | ||
liver | 0 (Control) | 2648.06±183.35 | 2436.80±1398.10 | 2741.66±137.60 | 2765.72±2093.37 |
100 | 4101.02±1105.19 | 3527.77±517.85* | 9634.45±5313.81* | ||
200 | 8504.29±3470.56* | 4068.79±232.22* | 7068.51±3294.60* | ||
bladder | 0 | 3449.71±209.77 | 3273.61±1415.96* | 3393.723±443.62 | 3681.79±100.181 |
100 | 11737.22±4084.48* | 3467.52±688.35 | 5170.27±739.32* | ||
200 | 10511.25±1472.25* | 3770.84±1072.36 | 3089.84±768.84 | ||
prostate | 0 | 2802.91±64.67 | 2756.19±1587.58 | 2876.72±2198.77 | 2775.82±1878.86 |
100 | 2310.67±226.59 | 5523.26±969.70* | 6807.09±1674.26* | ||
200 | 2337.18±1150. 77 | 5119.12±4551.13 | 6411.29±1356.39* | ||
lung | 0 | 4870.35±39.78 | 4851.78±527.02 | 4916.02±2880.84 | 4843.25±1181.73 |
100 | 3857.17±1549.93 | 4524.02±5647.48 | 3473.61±1628.91 | ||
200 | 4339.79±88.12 | 11079.75±1966.66* | 8950.10±2933.21 | ||
stomach | 0 | 60479.048±3081.32 | 64021.47±5996.13 | 59000.77±14874.92 | 58416.41±12850.78 |
100 | 57294.48±11656.99 | 50044.99±15353.51 | 91235.17±20875.47* | ||
200 | 74057.26±30492.55 | 59889.06±9694.78 | 69008.18±11494.82 | ||
Small intestine | 0 | 40637.76±1523.47 | 41885.29±4398.57 | 38927.15±2909.39 | 41100.84±18778.52 |
100 | 74065.44±8922.01 | 43262.27±1309.49* | 54448.36±9452.83* | ||
200 | 60568.51±2085.84 | 43810.33±472.22* | 47506.90±10479. 29 |
The data shown are means ± SD of five independent mice.
Statistically significant versus control group, P < 0.05 (t-test).