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. Author manuscript; available in PMC: 2015 Feb 18.
Published in final edited form as: J Med Chem. 2014 Feb 18;57(4):1188–1207. doi: 10.1021/jm401551n

Table 2.

graphic file with name nihms572303u3.jpg
Compd. X1 = X2 X3 X4 X5,X6 IC50 (μM) growth inhibitiona IC50 (μM) caspase-3,-7 activationb
36a C -H graphic file with name nihms572303t1.jpg 2x -OCH3 7.8±1.1 ND
36b C -H graphic file with name nihms572303t2.jpg 2x -OCH3 57±3 60±9
42a N -H graphic file with name nihms572303t3.jpg 2x -CH3 ND 6.0±2.1
42b N -H graphic file with name nihms572303t4.jpg 2x -CH3 20±5 32±3
42c N -H graphic file with name nihms572303t5.jpg 2x -CH3 35±10 45
a

Inhibition of growth measured in Kasumi-1 acute myeloid leukemia cells. Values are the mean ± SEM.

b

Caspase-3,7 activation measured in MOLM13 acute myeloid leukemia cells. Values are the mean ± SEM.