. Author manuscript; available in PMC: 2015 Feb 27.

Published in final edited form as: J Am Chem Soc. 2014 Feb 27;136(10):3788–3791. doi: 10.1021/ja500706v

Table 1. Catalytic Enantioselective Cyclization/Cross-Coupling with an Alkyl Electrophile: Influence of Reaction Parameters^a.


entry	variation from the “standard” conditions	ee (%)	yield (%)^b
1	none	96	82
2	no NiBr₂ • glyme	–	<5
3	no (S,S)–1	–	<5
4	no i-BuOH	–	<5
5	1.5 equiv of arylboron reagent	81	67
6	(S,S)–2, instead of (S,S)–1	39	64
7	(S,S)–3, instead of (S,S)–1	–	<5
8	(S,S)–4, instead of (S,S)–1	61	33
9	BnCH₂CH₂Cl, instead of BnCH₂CH₂Br	–	<5

All data are the average of two experiments.

The yield was determined by GC analysis with the aid of a calibrated internal standard.

Table 1. Catalytic Enantioselective Cyclization/Cross-Coupling with an Alkyl Electrophile: Influence of Reaction Parametersa.