Table 3.
Pathogen/Microbial-Associated Molecular Patterns (P/MAMP) and corresponding human Toll-like receptors (TLRs) and microbial source (Pathogen).
| P/MAMP | PRR | Pathogen |
|---|---|---|
| Peptidoglycan, Pam3CSK4a, Zymosan | TLR1 TLR2 TLR6b |
Gram Positive Bacteria |
| dsRNA | TLR3 | Virus |
| LPS, Lipid A | TLR4 | Gram Negative Bacteria |
| Flagellin | TLR5 | Bacteria, Flagellum |
| ssRNA | TLR7 TLR8 |
Virus |
| CpG DNA motifs | TLR9 | Bacteria, DNA |
| Profilin-like proteins | TLR10 |
a
synthetic triacylated lipopeptide
b
heterodimerizes with TLR1, TLR2