Table 1.
Symptoms and Complications at Baseline Among Olmsted County, MN, Residents With Paget’s Disease of Bone First Diagnosed in 1950–1994, by Prescreening (1950 to June 1974) and Postscreening (July 1974–1994) Time Periods
| 1950 to June 1974 (N = 109) | July 1974–1994 (N = 127) | p | |
|---|---|---|---|
| Age at diagnosis (mean ± SD) | 66.2 ± 11.1 | 72.6 ± 12.3 | <0.001 |
| Symptomatic presentation, any [N (%)] | 63 (58.9) | 71 (57.7) | 0.859 |
| Pain [N (%)] | 47 (43.9) | 48 (40.0) | 0.550 |
| Deformity [N (%)] | 13 (12.0) | 18 (14.6) | 0.563 |
| Warmth [N (%)] | 4 (3.7) | 1 (0.8) | 0.186 |
| Fracture [N (%)] | 4 (3.7) | 2 (1.6) | 0.421 |
| Other [N (%)] | 17 (15.7) | 28 (22.4) | 0.199 |
| Skeletal complications [N (%)] | 5 (4.6) | 5 (3.9) | 0.999 |
| Bowing deformities [N (%)] | 4 (3.7) | 2 (1.6) | 0.419 |
| Osteosarcoma [N (%)] | 0 (0) | 0 (0) | — |
| Fracture of pagetic bone [N (%)] | 1 (0.9) | 3 (2.4) | 0.626 |
| Nonskeletal complications [N (%)] | 6 (5.5) | 2 (1.6) | 0.149 |
| Cranial nerve compression [N (%)] | 0 (0) | 0 (0) | — |
| Basilar invagination [N (%)] | 1 (0.9) | 0 (0) | 0.462 |
| Peripheral nerve compression [N (%)] | 0 (0) | 0 (0) | — |
| Nerve root compression [N (%)] | 4 (3.7) | 0 (0) | 0.044 |
| CHF attributed to Paget’s disease [N (%)] | 1 (0.9) | 2 (1.6) | 0.999 |
| Nonspecific conditions [N (%)]* | 63 (64.9) | 89 (74.2) | 0.140 |
| Osteoarthritis [N (%)] | 45 (41.7) | 59 (46.8) | 0.428 |
| Hip or knee replacement [N (%)] | 1 (0.9) | 5 (3.9) | 0.221 |
| Hearing loss [N (%)]* | 10 (11.1) | 42 (41.6) | <0.001 |
| Tinnitus [N (%)] | 6 (5.6) | 11 (8.8) | 0.342 |
| Vertigo [N (%)] | 8 (7.4) | 25 (20.0) | 0.006 |
| Hypercalcemia [N (%)] | 1 (0.9) | 4 (3.2) | 0.376 |
| Gout [N (%)] | 2 (1.9) | 6 (4.8) | 0.292 |
| Kidney stones [N (%)] | 4 (3.7) | 11 (8.9) | 0.114 |
*
Forty-five patients with unknown date of diagnosis.