Table 2.
Symptoms at Presentation and Complications at Any Time Among Olmsted County, MN, Residents With Paget’s Disease of Bone First Diagnosed in 1950–1994
| Men (N = 129) | Women (N = 107) | Both sexes (N = 236) | |
|---|---|---|---|
| Age at diagnosis (mean ± SD) | 69.5 ± 11.9 | 69.8 ± 12.6 | 69.6 ± 12.2 |
| Symptomatic presentation [N (%)] | 67 (53.2) | 67 (64.4) | 134 (58.3) |
| Pain [N (%)] | 48 (38.7) | 47 (45.6) | 95 (41.9) |
| Deformity [N (%)] | 12 (9.4) | 19 (18.3) | 31 (13.4) |
| Warmth [N (%)] | 3 (2.4) | 2 (1.9) | 5 (2.2) |
| Fracture [N (%)] | 3 (2.3) | 3 (2.9) | 6 (2.6) |
| Other [N (%)] | 23 (18.0) | 22 (21.0) | 45 (19.3) |
| Skeletal complications [N (%)] | 14 (10.9) | 20 (18.7) | 34 (14.4) |
| Bowing deformities [N (%)] | 8 (6.2) | 10 (9.3) | 18 (7.6) |
| Osteosarcoma [N (%)] | 1 (0.8) | 0 (0.0) | 1 (0.4) |
| Fracture of pagetic bone [N (%)] | 9 (7.0) | 14 (13.1) | 23 (9.7) |
| Nonskeletal complications [N (%)] | 10 (7.8) | 12 (11.2) | 22 (9.3) |
| Cranial nerve compression [N (%)] | 0 (0.0) | 1 (0.9) | 1 (0.4) |
| Basilar invagination [N (%)] | 1 (0.8) | 4 (3.7) | 5 (2.1) |
| Peripheral nerve compression [N (%)] | 1 (0.8) | 3 (2.8) | 4 (1.7) |
| Nerve root compression [N (%)] | 5 (3.9) | 4 (3.7) | 9 (3.8) |
| CHF attributed to Paget’s disease [N (%)] | 4 (3.1) | 3 (2.8) | 7 (3.0) |
| Nonspecific conditions [N (%)] | 113 (88.3) | 97 (91.5) | 210 (89.7) |
| Osteoarthritis [N (%)] | 89 (69.5) | 81 (76.4) | 170 (72.6) |
| Hip or knee replacement [N (%)] | 15 (11.6) | 10 (9.3) | 25 (10.6) |
| Hearing loss [N (%)] | 79 (61.2) | 66 (61.7) | 145 (61.4) |
| Tinnitus [N (%)] | 15 (11.8) | 27 (25.5) | 42 (18.0) |
| Vertigo [N (%)] | 25 (19.7) | 32 (30.2) | 57 (24.5) |
| Hypercalcemia [N (%)] | 3 (2.4) | 9 (8.5) | 12 (5.2) |
| Gout [N (%)] | 13 (10.3) | 6 (5.7) | 19 (8.2) |
| Kidney stones [N (%)] | 18 (14.4) | 9 (8.5) | 27 (11.7) |