Online Appendix Table 1.

Age-and sex-adjusted rates of hypertension, elevated levels of low-density lipoprotein cholesterol, type 2 diabetes, treatment and control among WC categories

	% of Participants (95% CI)
	WC <88 or 102	WC ≥88 or 102	p-value*
	N=3558	N=3243
Hypertension
Prevalence	13.5 (12.3–14.8)	33.0 (31.0–35.1)	<0.001
Treatment	54.2 (47.6–60.6)	63.9 (59.0–68.5)	0.009
Control	36.7 (31.7–41.9)	38.6 (35.2–42.2)	0.78
Elevated LDL-C
Prevalence	16.3 (15.0–17.7)	33.0 (31.0–35.1)	<0.001
Treatment	33.7 (29.4–38.3)	39.2 (35.6–42.8)	0.05
Control	24.5 (20.8–28.4)	29.0 (26.0–32.1)	0.09
Diabetes
Prevalence	1.8 (1.3–2.2)	8.9 (7.9–10.0)	<0.001
Treatment	62.5 (40.6–81.2)	53.3 (44.6–61.9)	0.19
Hb A1c <7% †	55.6 (30.8–78.5)	50.5 (40.3–60.7)	0.75
FPG <126 mg/dL	25.5 (13.9–40.4)	16.9 (12.5–22.2)	0.08

Abbreviations: CI, confidence interval; WC, waist circumference; LDL-C, low-density lipoprotein cholesterol; Hb A1c, Hemoglobin A_1c level; FPG, fasting plasma glucose

SI conversion factor: To convert fasting plasma glucose to mmol/L, multiply mg/dL values by 0.0555

^*Global GEE p-value

^†Data only available for Offspring cohort