Micro-CT of RT2 tumors in Shb+/+RT and Shb+/−RT mice. (A) Examples of afferent vascular networks of large (a, b) and small (c, d) tumors of each genotype (a, c for +/+ and b, d for +/−). Scale bar indicates 400 mm. (B) Vascular density in each size range for Shb+/+ (n = 3) and Shb+/− (n = 5) tumors. Means ± SEM are given. And values are vessel diameter in µm. p < 0.001 when comparing the vascular density over all size ranges. (C) Relative size distribution. For each tumor, the percentage vascular density in each size interval was determined in percent of total vascular density for that tumor. Means ± SEM are given. * indicates p<0.05 when compared with wild-type control by a paired Student’s t-test.