Table 3.

Alterations in transporter expression observed in the presence of various types of liver impairment.

Transporter	Function	Change in Transporter Expression	Type of Liver Impairment	References
BCRP	Efflux	↑	ALF, PBC	[Barnes et al., 2007, Li et al., 2009, Giacomini et al., 2011]
BSEP	Efflux	↔	PBC	[Zollner et al., 2003, Giacomini et al., 2011]
MDR1	Efflux	↑	ALF, PBC	[Zollner et al., 2003, Ho et al., 2005, Barnes et al., 2007, Li et al., 2009, Giacomini et al., 2011]
MDR2	Efflux	↑	ALF, PBC	[Li et al., 2009]
MDR3	Efflux	↑	ALF, PBC	[Zollner et al., 2003, Li et al., 2009, Giacomini et al., 2011]
MRP1	Efflux	↑	PBC	[Barnes et al., 2007, Li et al., 2009, Giacomini et al., 2011]
MRP2	Efflux	↔	PBC	[Zollner et al., 2003]
MRP3	Efflux	↑	PBC	[Zollner et al., 2003, Barnes et al., 2007, Giacomini et al., 2011]
MRP4	Efflux	↑	ALF, PBC	[Barnes et al., 2007, Giacomini et al., 2011]
MRP5	Efflux	↑	ALF, PBC	[Barnes et al., 2007]
NTCP	Uptake	↓	PBC	[Zollner et al., 2003, Li et al., 2009]
OATP1a4	Uptake	↓	PBC	[Li et al., 2009, Giacomini et al., 2011]
OATP2	Uptake/Efflux	↓	PBC	[Zollner et al., 2003]

Abbreviations: PBC – Primary Biliary Cirrhosis, ALF – Acute Liver Failure