. Author manuscript; available in PMC: 2015 Mar 24.

Published in final edited form as: Cell Mol Life Sci. 2012 May 15;69(14):2315–2325. doi: 10.1007/s00018-012-1009-2

Table 1.

Isoform specificity of small molecule inhibitors of NADPH oxidase

Name	IC50s (μM)				References
	Nox1	Nox2	Nox4	XO
VAS2870	↓	10.6 (Neutrophils) 2 (HL-60)	↓	?	[52-58]
VAS3947	↓	1–2 (HL-60 cells)	↓	-	[60]
Fulvene-5	?	↓	↓	?	[63]
ML171	0.25	5.00	5.00	5.50	[70]
GKT 136901	0.160^a	1.530^a	0.165^a	30^a	[64-66, 79, 80]
Celastrol	0.41	0.59	2.7	-	[74]

↓ inhibits, - no effect, ? not determined

K_i in μM