Table 1.
Up-regulated and down-regulated miRNAs in stage I SCC and AC tissues defined by deep sequencing
| SCC
|
AC
|
||||
|---|---|---|---|---|---|
| miRNAs | Fold-change (tumor/normal) | p.Value | miRNAs | Fold-change (tumor/normal) | p.Value |
|
|
|
||||
| miR-548a-3p | 12.308824 | 0.00012743 | miR-431-5p | 6.317018 | 2.91617E-06 |
| miR-1291 | 8.060843 | 2.43E-23 | miR-323a-3p | 5.698014 | 2.542E-05 |
| miR-205-5p | 6.173350 | 1.56E-15 | miR-9-3p | 5.518930 | 6.29421E-05 |
| miR-147b | 5.515700 | 1.20E-07 | miR-196a-5p | 5.452727 | 9.32211E-06 |
| miR-183-3p | 5.404806 | 4.68E-06 | miR-668 | 5.260027 | 0.000104731 |
| miR-1269b | 5.401679 | 1.08E-06 | miR-376b-3p | 5.118238 | 0.000128737 |
| miR-944 | 5.342495 | 2.26E-11 | miR-182-3p | 4.804702 | 0.000568362 |
| miR-9-5p | 5.304565 | 1.85E-12 | miR-4435 | 4.583124 | 0.000231087 |
| miR-205-3p | 4.829734 | 0.000325 | miR-21-5p | 4.485680 | 3.45658E-05 |
| miR-196a-5p | 4.771010 | 9.80E-10 | miR-196a-3p | 4.482990 | 9.99902E-06 |
| miR-577 | 4.687445 | 8.85E-06 | miR-1185-1-3p | 4.430215 | 0.000608887 |
| miR-335-3p | 4.500000 | 3.45E-05 | miR-431-3p | 4.404831 | 0.000671589 |
| miR-21-5p | 4.480231 | 1.11E-06 | miR-1197 | 4.388206 | 0.000327892 |
| miR-3609 | 4.463120 | 2.85E-12 | miR-323b-3p | 4.369117 | 0.000691047 |
| miR-1910 | 3.899553 | 7.82E-05 | miR-9-5p | 4.366718 | 2.97523E-05 |
| miR-149-5p | 3.842863 | 6.61E-07 | miR-487a | 4.332483 | 0.000695979 |
| miR-873-3p | 3.679904 | 3.11E-05 | miR-380-3p | 4.303067 | 0.000425358 |
| miR-758-3p | 3.335272 | 0.000736 | miR-577 | 4.005734 | 0.001037253 |
| miR-301b | 3.309103 | 2.99E-05 | miR-410 | 3.966207 | 0.000198251 |
| miR-708-5p | 3.191239 | 5.37E-06 | miR-192-5p | 2.789685 | 0.0001095 |
| miR-31-5p | 3.180813 | 1.36E-05 | miR-451a | −2.526477 | 0.001015833 |
| miR-3676-5p | 3.091173 | 0.00013327 | miR-30a-5p | −2.851723 | 1.60505E-05 |
| miR-31-3p | 3.063404 | 0.00025179 | miR-486-3p | −3.131728 | 2.68134E-05 |
| miR-224-5p | 2.979244 | 6.61E-05 | miR-490-3p | −4.131157 | 0.000875453 |
| miR-873-5p | 2.923541 | 0.00189254 | miR-30a-5p | −4.453866 | 1.12345E-05 |
| miR-708-3p | 2.865219 | 0.00017849 | miR-30a-3p | −4.516783 | 2.34568E-05 |
| miR-183-5p | 2.793837 | 0.00015804 | miR-486-5p | −4.538656 | 1.12345E-05 |
| miR-409-5p | 2.726459 | 0.00017722 | miR-184 | −4.934109 | 4.68414E-05 |
| miR-449c-5p | −2.502744 | 0.00114347 | |||
| miR-3614-5p | −2.530638 | 0.00047691 | |||
| miR-223-5p | −2.646799 | 7.93E-05 | |||
| miR-29b-1-5p | −2.868420 | 0.00031147 | |||
| miR-30c-2-3p | −3.077404 | 3.17E-05 | |||
| miR-486-3p | −3.338364 | 2.76E-07 | |||
| miR-138-1-3p | −3.407908 | 0.00095397 | |||
| miR-30a-3p | −4.656785 | 1.25E-05 | |||
| miR-486-5p | −4.689655 | 1.23E-07 | |||
| miR-184 | −5.019975 | 3.00E-07 | |||
| miR-135a-5p | −5.067272 | 5.70E-06 | |||
| miR-375 | −6.320925 | 4.08E-18 | |||
SCC, squamous cell carcinoma; AC, adenocarcinoma.
Based on a 2.5-fold change cut-off value, 40 and 28 miRNAs show different level between stage I SCC or AC and normal tissues.
Based on a 4.5-fold change cut-off, 17 and 11 miRNAs (bold font) display dysregulation in either SCC or AC as shown in Fig. 1C.