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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: ACS Nano. 2014 Apr 11;8(5):4621–4629. doi: 10.1021/nn5003024

Figure 1.

Figure 1

a) Schematic illustration of the unique mechanism governing the NanoSubstrate-Mediated Delivery (NSMD) approach for both in vivo and in vitro settings. b) The multivalent molecular recognition between the Ad motifs on Ad-SiNWS and the β-cyclodextrin (CD) motifs on the surfaces of SNPs leads to dynamic assembly and local enrichment of SNPs onto Ad-SiNWS. The Ad/CD recognition system is also responsible for the supramolecular assembly of DNA⊂SNPs from the three molecular building blocks (i.e., CD-PEI, Ad-PAMAM, and Ad-PEG) and plasmid DNA.