Cationicity is involved in protection of host DNA against bacterial nuclease-mediated degradation. Sequences and biochemical characteristics of LL-37, LL-37 fragments, scrambled LL-37 (Scr. LL-37), hBD-3 and HNP-1 (a). Quantification of DNA-degradation by 100 U/ml S. aureus nuclease (micrococcal nuclease, MN) in the presence or absence of 5 μM LL-37, LL-37 fragments, scrambled LL-37 (b) or 5 μM HNP-1 and hBD-3 ((c) and (d)). All graphs represent the mean ± SEM of minimum 3 independent experiments. * p < 0.05, ** p < 0.005 by t-test.