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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Brain Pathol. 2015 Apr 20;25(4):391–400. doi: 10.1111/bpa.12161

Figure 4.

Figure 4

Loss of Sparc promotes macrophage activation and phagocytosis of p53-null astrocytes. Day 7 and day 50 p53-null/Sparc-wt and p53-null/Sparc-null tumor xenograft sections were immunohistochemically stained for CD68 and for periodic acid Schiff (PAS) +/−diastase (D) to assess the presence of microglia/macrophages. Images were taken at 40x magnification with insets at 60x. Representative images from 2 animals out of n = 6 animals/group for day 7 and n = 5 (Sparc-null) or 8 (Sparc-wt) animals/group for day 50.