Skip to main content
. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Mol Oncol. 2014 May 21;8(7):1355–1364. doi: 10.1016/j.molonc.2014.05.006

Figure 5.

Figure 5

SLUG sumoylation is essential for its protein stability. (A) Interaction between SLUG and SUMO1 for sumoylation. (B) SLUG mutation at K192R decreases SLUG protein levels. (C) Localization of SLUGK192R Pin nucleus of 293FT cells. Myc-tag antibody was used to detect Myc-SLUG. Bars equal 10 μm. (D) SLUGK192R decreases the protein stability compared to SLUGWT. (E) SLUGK192R decreases the interaction with SUMO1 compared to SLUGWT. (F) ARF promotes the interaction between SUMO1 and SLUG for sumoylation.