Table 3.
High-performance liquid chromatography measurements for markers of the serotonin and catecholamine systems in the occipital cortex in the fetal baboon model of prenatal nicotine exposure
| Measure | Control Mean ± SEM (range) (n=5) |
Nicotine-exposed Mean ± SEM (range) (n=5) |
FDR corrected p-value |
|---|---|---|---|
| 5-HT (pmol/mg protein) | 4.33 ± 0.59 (3.2, 6.1) |
3.65 ± 0.40 (2.9, 5.1) |
0.40 W |
| 5-HIAA (pmol/mg protein) | 11.06 ± 1.45 (8.2, 16.6) |
14.04 ± 1.23 (10.7, 17.0) |
0.35 |
| Norepinephrine (pmol/mg protein) |
5.53 ± 2.63 (0, 15.1) |
1.81 ± 0.50 (0.5, 3.4) |
0.42W |
| Dopamine (pmol/mg protein) | 3.25 ± 0.45 (1.9, 4.5) |
1.81 ± 0.14 (1.3, 2.1) |
0.21 |
| DOPAC (pmol/mg protein) | 36.88 ± 7.59 (18.6, 64.5) |
34.76 ± 7.67 (21.6, 64.1) |
0.71W |
| 5-HIAA:5HT ratio | 2.62 ± 0.24 (1.9, 3.2) |
4.11 ± 0.65 (2.1, 5.3) |
0.24 |
| DOPAC: dopamine ratio | 12.26 ± 2.70 (4.9, 19.2) |
21.17 ± 7.11 (11.2, 49.3) |
0.50W |
W
Legend: Wilcoxon Rank Sum used instead of t-test (see Materials and Methods). FDR: false discovery rate.