Skip to main content
. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Mol Oncol. 2014 Jun 3;8(8):1419–1428. doi: 10.1016/j.molonc.2014.05.012

Figure 5. AURKA regulates JAK2 expression.

Figure 5

(A) Silencing AURKA (siAURKA) in FLO-1 cells led to decreased JAK2 at both protein and mRNA levels. (B) FLO-1 cells stably overexpressing AURKA showed an increase in JAK2 at both protein and mRNA levels. (C-D) Inhibition of JAK2 using pharmacologic inhibitor (AZD1480) (C) or genetic knockdown JAK2 using siRNA (siJAK2) (D) abrogated AURKA-induced phosphorylation of STAT3 in FLO-1 cells.