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. Author manuscript; available in PMC: 2014 Jul 5.
Published in final edited form as: Biosensors (Basel). 2013;3(3):259–282. doi: 10.3390/bios3030259

Figure 4.

Figure 4

A) The deoxy ferrous form of DosS/DosT is autophosphorylated under hypoxia or upon binding CO or NO, while no phosphorylation is observed when the proteins bind oxygen. The phosphorylated protein transfers the phosphate group to DosR, which then binds DNA resulting in downstream signaling leading to the upregulation of the 47 other genes necessary for dormancy. B) DosT is sensitive to low oxygen concentrations inside the cell and responds during the early transition from aerobic to hypoxia by autophosphorylation and induction of the dosR regulon. DosS detects hypoxia at later stages and is responsible for maintaining the dormancy regulon induction.