Table 2.

Scope of Pd-Catalyzed Carboamination^a

fileentry	R1	R	product	yield (%)b	drc (crude)
1	H	Ph	10a	89	7:1
2	H	p-tBu-C6H4	10b	78	6:1
3	H	p-MeO-C6H4	10c	70	7:1
4	H	p-benzophenone	10d	61d	8:1 (5:1)
5	H	o-Me-C6H4	10e	87	5:1
6	H	1-cyclohexenyl	10f	63d	6:1
7	H	1-decenyl	10g	45d	10:1[f,g]
8	allyl	Ph	10h	65e	20:1 (12:1)
9	allyl	P-MeO-C6H4	10i	63e	>20:1 (13:1)

^aReaction Conditions: 1.0 equiv 9a or 9b, 2.0 equiv R-OTf, 2.0 equiv LiO^tBu, 4 mol % Pd(OAc)₂, 10 mol % C-Phos, ^tBuOH (0.1 M), 82 °C, 16 h.

^bIsolated yield (average of two or more runs).

^cDiastereomeric ratio of the pure isolated material. Diastereomeric ratios of isolated materials were identical to those of the crude products unless otherwise noted.

^dThe reaction was conducted with 3.0 equiv of LiOtBu and 3.0 equiv R-OTf.

^eThe reaction time was 2 h.

^f1-Decenyl triflate was employed as 5:1 mixture of E:Z isomers.

^gThe dr was determined following hydrogenation of 10g. The crude dr of 10g could not be determined directly due to the mixture of diastereomers and E/Z isomer products. However, we estimate the crude dr to be ca. 5-10:1.