Table 2.
Associations between MLN, MLNR, SSTR2 and SSTR5 genotypes with the risk of biliary tract cancers and stones.
| Genotype | Controls | Biliary stones† | Biliary tract cancer |
||||||
|---|---|---|---|---|---|---|---|---|---|
| n(%) | n(%) | OR¶ (95%CI) | Gallbladder‡ | Bile duct § | A.V. § | ||||
| n(%) | OR¶ (95%CI) | n(%) | OR¶ (95%CI) | n(%) | OR¶ (95%CI) | ||||
| MLN | 477 | 439 | 253 | 133 | 53 | ||||
| rs2281820 | |||||||||
| CC | 346(77.6) | 317(73.9) | 1.00 | 189(74.7) | 1.00 | 94(70.7) | 1.00 | 39(75.0) | 1.00 |
| CT | 92(20.6) | 107(24.9) | 1.52(1.06-2.18) | 62(24.5) | 1.30(0.89-1.90) | 37(27.8) | 1.48(0.94-2.33) | 13(25.0) | 1.25(0.63-2.45) |
| TT | 8(1.8) | 5(1.2) | 0.58(0.18-1.82) | 2(0.8) | - | 2(1.5) | - | - | - |
| CT±TT | 100(22.4) | 112(26.1) | 1.42(1.00-2.00) | 64(25.3) | 1.23(0.85-1.79) | 39(29.3) | 1.42(0.91-2.21) | 13(25.0) | 1.13(0.57-2.20) |
| P trend | 0.03 | 0.20 | 0.09 | 0.59 | |||||
| Rs3793079 | |||||||||
| AA | 295(66.1) | 246(57.3) | 1.00 | 162(64.0) | 1.00 | 75(56.4) | 1.00 | 32(61.5) | 1.00 |
| AT | 135(30.3) | 166(38.7) | 1.64(1.20-2.25) | 80(31.6) | 1.08(0.77-1.53) | 54(40.6) | 1.58(1.04-2.38) | 18(34.6) | 1.19(0.64-2.21) |
| TT | 16(3.6) | 17(4.0) | 1.15(0.55-2.38) | 11(4.4) | 1.26(0.56-2.80) | 4(3.0) | - | 2(3.9) | - |
| AT±TT | 151(33.9) | 183(42.7) | 1.58(1.17-2.13) | 91(36.0) | 1.10(0.79-1.54) | 58(43.6) | 1.49(1.00-2.23) | 20(38.5) | 1.18(0.65-2.14) |
| P trend | 0.002 | 0.62 | 0.03 | 0.58 | |||||
| Rs2281819 | |||||||||
| AA | 343(76.9) | 315(73.4) | 1.00 | 181(71.5) | 1.00 | 95(71.4) | 1.00 | 40(76.9) | 1.00 |
| AT | 99(22.2) | 108(25.2) | 1.34(0.95-1.90) | 71(28.1) | 1.39(0.97-2.01) | 36(27.1) | 1.31(0.83-2.05) | 11(21.2) | 0.90(0.44-1.83) |
| TT | 4(0.9) | 6(1.4) | - | 1(0.4) | - | 2(1.5) | - | 1(1.9) | - |
| AT±TT | 103(23.1) | 114(26.6) | 1.33(0.95-1.87) | 72(28.5) | 1.35(0.94-1.94) | 38(28.6) | 1.32(0.85-2.06) | 12(23.1) | 0.95(0.48-1.88) |
| P trend | 0.10 | 0.08 | 0.23 | 0.81 | |||||
| MLNR | |||||||||
| Rs9568169 | |||||||||
| CC | 151(33.9) | 129(30.1) | 1.00 | 89(35.2) | 1.00 | 54(40.6) | 1.00 | 19(36.5) | 1.00 |
| CA | 199(44.6) | 212(49.5) | 1.30(0.93-1.81) | 115(45.4) | 1.00(0.70-1.42) | 61(45.9) | 0.86(056-1.32) | 25(48.1) | 1.00(0.53-1.90) |
| AA | 96(21.5) | 87(20.3) | 1.29(0.85-1.95) | 49(19.4) | 0.95(0.61-1.48) | 18(13.5) | 0.49(0.27-0.89) | 8(15.4) | 0.59(0.25-1.41) |
| CA±AA | 295(66.1) | 299(69.9) | 1.30(0.95-1.77) | 164(64.8) | 0.98(0.71-1.37) | 79(59.4) | 0.73(0.49-1.10) | 33(63.5) | 0.86(0.47-1.57) |
| P trend | 0.13 | 1.00 | 0.56 | 0.93 | |||||
| SSTR2 | |||||||||
| Rs7210080 | |||||||||
| TT | 230(51.6) | 215(50.1) | 1.00 | 117(46.2) | 1.00 | 75(56.4) | 1.00 | 28(53.9) | 1.00 |
| TC | 176(39.4) | 183(42.7) | 1.04(0.77-1.41) | 112(44.3) | 1.25(0.90-1.74) | 47(35.3) | 0.82(0.54-1.25) | 17(32.7) | 0.78(0.41-1.48) |
| CC | 40(9.0) | 31(7.2) | 0.70(0.41-1.20) | 24(9.5) | 1.12(0.64-1.97) | 11(8.3) | 0.83(0.40-1.71) | 7(13.4) | 1.50(0.61-3.70) |
| TC+CC | 216(48.4) | 214(49.9) | 0.97(0.73-1.30) | 136(53.8) | 1.23(0.89-1.68) | 58(43.6) | 0.82(0.55-1.22) | 24(46.1) | 0.91(0.51-1.62) |
| P trend | 0.84 | 0.19 | 0.35 | 0.49 | |||||
| Rs1466113 | |||||||||
| GG | 121(27.1) | 112(26.1) | 1.00 | 76(30.0) | 1.00 | 34(25.6) | 1.00 | 16(30.8) | 1.00 |
| GC | 240(53.8) | 221(51.5) | 1.08(0.76-1.51) | 120(47.5) | 0.83(0.58-1.20) | 65(48.9) | 0.96(0.60-1.55) | 18(34.6) | 0.53(0.26-1.09) |
| CC | 85(19.1) | 96(22.4) | 1.31(0.85-2.01) | 57(22.5) | 1.12(0.71-1.75) | 34(25.5) | 1.46(0.84-2.56) | 18(34.6) | 1.63(0.78-3.41) |
| GC+CC | 325(72.9) | 317(73.9) | 1.14(0.82-1.57) | 177(70.0) | 0.91(0.64-1.28) | 99(74.4) | 1.09(0.70-1.71) | 36(69.2) | 0.81(0.43-1.52) |
| P trend | 0.82 | 0.26 | 0.69 | 0.05 | |||||
| Rs2236748 | |||||||||
| GG | 304(68.2) | 315(73.6) | 1.00 | 185(73.1) | 1.00 | 92(69.2) | 1.00 | 42(80.8) | 1.00 |
| GA | 126(28.2) | 108(25.2) | 0.91(0.65-1.27) | 64(25.3) | 0.83(0.58-1.20) | 38(28.6) | 1.02(0.66-1.59) | 10(19.2) | 0.58(0.28-1.20) |
| AA | 16(3.6) | 5(1.2) | - | 4(1.6) | - | 3(2.2) | - | - | - |
| GA+AA | 142(31.8) | 114(26.4) | 0.83(0.61-1.15) | 68(26.9) | 0.79(0.55-1.12) | 41(30.8) | 0.97(0.63-1.48) | 10(19.2) | 0.51(0.25-1.06) |
| P trend | 0.45 | 0.27 | 0.98 | ||||||
| Rs2236750 | |||||||||
| GG | 122(27.5) | 138(32.2) | 1.00 | 73(28.9) | 1.00 | 47(35.3) | 1.00 | 21(40.4) | 1.00 |
| GA | 231(52.0) | 214(49.9) | 0.78(0.56-1.10) | 124(49.0) | 0.92(0.63-1.33) | 62(46.6) | 0.67(0.43-1.05) | 21(40.4) | 0.49(0.26-0.94) |
| AA | 91(20.5) | 77(17.9) | 0.70(0.46-1.07) | 56(22.1) | 1.00(0.64-1.57) | 24(18.1) | 0.68(0.38-1.20) | 10(19.2) | 0.65(0.29-1.46) |
| GA+AA | 322(72.5) | 291(67.8) | 0.76(0.55-1.05) | 180(71.1) | 0.94(0.66-1.34) | 86(64.7) | 0.67(0.44-1.02) | 31(59.6) | 0.53(0.29-0.97) |
| P trend | 0.20 | 0.63 | 0.09 | 0.03 | |||||
| SSTR5 | |||||||||
| Rs169068 | |||||||||
| TT | 268(60.2) | 259(61.5) | 1.00 | 160(63.5) | 1.00 | 79(59.4) | 1.00 | 28(53.9) | 1.00 |
| TC | 157(35.3) | 145(34.4) | 0.91(0.67-1.24) | 80(31.7) | 0.82(0.59-1.15) | 41(30.8) | 0.92(0.60-1.42) | 21(40.4) | 1.29(0.71-2.37) |
| CC | 20(4.5) | 17(4.0) | 1.02(0.49-2.13) | 12(4.8) | 0.95(0.44-2.05) | 13(9.8) | 2.40(1.13-5.13) | 3(5.8) | - |
| TC+CC | 177(39.8) | 162(38.5) | 0.92(0.69-1.24) | 92(36.5) | 0.84(0.60-1.16) | 54(40.6) | 1.08(0.72-1.62) | 24(46.1) | 1.32(0.74-2.37) |
| P trend | 0.57 | 0.26 | 0.84 | 0.39 | |||||
OR, odds ratio; 95% CI, 95% confidence interval.
†
Biliary stone (gallstone and bile duct stone) cases were compared to controls without biliary stones (n = 341).
‡
Gallbadder cancer cases were compared with population controls who never had a cholecystectomy (n = 422).
§
Bile duct and ampulla of Vater cancer cases were compared with all population controls (n = 447).
¶
Adjusted for age and gender.
Test of trend for the number of copies of the variant allele (0, 1 and 2).
Did not calculate OR when N was less than 5.