Table 1.
Cohort Baseline Characteristics by Age Quartile.
| Total | Age quartiles (Years) | P-value | ||||
|---|---|---|---|---|---|---|
| Q1 (30–62) | Q2 (63–71) | Q3 (72–77) | Q4 (78–93) | |||
| Number of individuals | 2364 | 597 | 574 | 589 | 604 | |
| Women (%) | 55.8 | 57.0 | 57.8 | 58.2 | 50.5 | 0.0357 |
| BMI (kg/m2) (mean ± SD) | 24.9 ± 3.7 | 25.5 ± 4.0 | 25.2 ± 3.7 | 24.7 ± 3.6 | 24.4 ± 3.4 | <0.0001 |
| Alcohol use (%) | <0.0001 | |||||
| None | 36.8 | 36.5 | 34.8 | 32.1 | 43.4 | |
| <1 drink/day | 22.0 | 25.0 | 18.8 | 22.6 | 21.4 | |
| 1–2 drinks/day | 26.8 | 22.5 | 27.0 | 31.4 | 26.5 | |
| >2 drinks/day | 14.5 | 16.1 | 19.3 | 13.9 | 8.8 | |
| Bilirubin (mg/dl) (95% CI)a | 0.50 (0.49–0.51) | 0.43 (0.41–0.44) | 0.49 (0.47–0.51) | 0.53 (0.51–0.55) | 0.56 (0.54–0.58) | <0.0001 |
| Systolic blood pressure (mmHg) (mean ± SD) |
138.9 ± 21.9 | 124.0 ± 18.4 | 136.3 ± 18.7 | 144.5 ± 19.2 | 150.7 ± 21.5 | <0.0001 |
| Total cholesterol (mg/dl) (mean ± SD) |
219.9 ± 40.0 | 218.7 ± 36.6 | 228.1 ± 41.5 | 219.6 ± 40.5 | 213.5 ± 39.9 | 0.0009 |
| HDL cholesterol (mg/dL) (mean ± SD) |
61.7 ± 18.7 | 60.9 ± 18.2 | 62.3 ± 19.9 | 62.9 ± 20.1 | 60.9 ± 16.7 | 0.8538 |
| Total/HDL cholesterol ratio (mean ± SD) |
3.9 ± 1.3 | 3.9 ± 1.3 | 4.0 ± 1.3 | 3.8 ± 1.3 | 3.9 ± 1.2 | 0.0120 |
| Triglycerides (mg/dl) (95% CI)a |
102.0 (99.8–104.3) | 100.2 (95.9–104.7) | 111.3 (106.4–116.4) | 101.7 (97.3–106.3) | 95.8 (91.7–100.1) | 0.0245 |
| Smoking (%)b | 58.2 | 55.4 | 65.0 | 61.3 | 51.3 | 0.0755 |
| Diabetes (%) | 14.3 | 7.4 | 12.5 | 17.7 | 19.7 | <0.0001 |
| AST (IU/L) (95% CI)a | 24.6 (24.3–25.0) | 23.4 (22.7–24.2) | 24.7 (24.0–25.5) | 25.0 (24.3–25.8) | 25.4 (24.6–26.1) | 0.0003 |
| ALT (IU/L) (95% CI)a | 17.4 (17.1–17.8) | 19.6 (18.9–24.2) | 18.1 (17.4–18.9) | 16.9 (16.2–17.6) | 15.4 (14.8–16.1) | <0.0001 |
| GGT (IU/L) (95% CI)a | 9.8 (9.5–10.1) | 9.7 (9.1–10.2) | 10.5 (9.9–11.1) | 9.9 (9.3–10.4) | 9.2 (8.8–9.9) | 0.2000 |
| Albumin (g/dL) (mean ± SD) | 4.3 ± 0.3 | 4.4 ± 0.2 | 4.4 ± 0.3 | 4.2 ± 0.3 | 4.1 ± 0.2 | <0.0001 |
a
Geometric means (95% CI).
b
Current or prior smoking
Q1: quartile 1, Q2: quartile 2, Q3: quartile 3, Q4: quartile 4, BMI: body mass index, kg: kilogram, m: meter, SD: standard deviation, mg: milligram, dl: deciliter, CI: confidence interval, mmHg: millimeter mercury, HDL: high density lipoprotein, AST: aspartate aminotransferase, ALT: alanine aminotransferase, IU: international units, L: liter, GGT: gamma-glutamyl transferase, g: grams.