Table 2.
Cohort Baseline Characteristics by Bilirubin Quartile.
| Total | Bilirubin quartiles (mg/dl) | P-value | ||||
|---|---|---|---|---|---|---|
| Q1 (0.1–0.3) | Q2 (0.4–0.5) | Q3 (0.6–0.6) | Q4 (0.7–2.3) | |||
| Number of Individuals | 2363 | 465 | 895 | 334 | 669 | |
| Women (%) | 55.8 | 75.1 | 63.4 | 50.6 | 35.0 | <0.0001 |
| BMI (kg/m2) (Mean ± SD) | 24.9 ± 3.7 | 25.0 ± 4.1 | 24.8 ± 3.5 | 25.0 ± 3.9 | 25.0 ± 3.5 | 0.8271 |
| Alcohol use (%) | 0.0059 | |||||
| None | 36.8 | 43.4 | 38.2 | 32.9 | 32.1 | |
| <1 drink/day | 21.9 | 20.2 | 22.6 | 24.0 | 21.2 | |
| 1–2 drinks/day | 26.8 | 25.2 | 24.9 | 28.1 | 29.9 | |
| >2 drinks/day | 14.5 | 11.2 | 14.3 | 15.0 | 16.7 | |
| Systolic blood pressure (mmHg) (Mean ± SD) | 138.9 ± 21.9 | 135.2 ± 23.7 | 138.5 ± 21.7 | 139.3 ± 20.6 | 142.0 ± 21.1 | <0.0001 |
| Total cholesterol (mg/dl) (mean ± SD) | 219.9 ± 40.0 | 222.6 ± 40.0 | 224.4 ± 39.7 | 219.2 ± 39.9 | 212.1 ± 39.2 | <0.0001 |
| HDL cholesterol (mg/dL) (mean ± SD) | 61.7 ± 18.7 | 63.4 ± 18.6 | 62.4 ± 18.9 | 61.3 ± 17.4 | 59.8 ± 19.0 | 0.0012 |
| Total/HDL cholesterol ratio (mean ± SD) | 3.9 ± 1.3 | 3.8 ± 1.3 | 3.9 ± 1.4 | 3.8 ± 1.2 | 3.8 ± 1.3 | 0.9369 |
| Triglycerides (mg/dl) (95% CI)a | 102.0 (99.8–104.3) | 107.8 (102.5–113.3) | 103.0 (99.3–106.7) | 102.1 (96.3–108.3) | 97.0 (93.0–101.1) | 0.0021 |
| Smoking (%)b | 58.2 | 58.5 | 57.2 | 56.9 | 59.9 | 0.5030 |
| Diabetes (%) | 14.3 | 12.5 | 13.6 | 11.4 | 18.1 | 0.0092 |
| AST (IU/L) (95% CI)a | 24.6 (24.3–25.0) | 22.4 (21.6–23.1) | 24.2 (23.6–24.8) | 25.8 (24.8–26.9) | 26.3 (25.6–27.1) | <0.0001 |
| ALT (IU/L) (95% CI)a | 17.4 (17.1–17.8) | 16.3 (15.6–17.1) | 17.5 (17.0–18.1) | 17.9 (16.9–18.9) | 17.9 (17.2–18.6) | 0.0034 |
| GGT (IU/L) (95% CI)a | 9.8 (9.5–10.1) | 8.9 (8.4–9.5) | 9.6 (9.2–10.1) | 9.8 (9.1–10.6) | 10.7 (10.1–11.3) | <0.0001 |
| Albumin (g/dL) (mean ± SD) | 4.3 ± 0.3 | 4.3 ± 0.3 | 4.3 ± 0.3 | 4.3 ± 0.3 | 4.3 ± 0.3 | 0.0955 |
a
Geometric means (95% confidence interval).
b
Current or prior smoking
Q1: quartile 1, Q2: quartile 2, Q3: quartile 3, Q4: quartile 4, BMI: body mass index, kg: kilogram, m: meter, SD: standard deviation, mg: milligram, dl: deciliter, CI: confidence interval, mmHg: millimeter mercury, HDL: high density lipoprotein, AST: aspartate aminotransferase, ALT: alanine aminotransferase, IU: international units, L: liter, GGT: gamma-glutamyl transferase, g: grams.