Table 5.
Cytokine | N | Median (Range) |
Median fold
chg(Range) |
p-value |
---|---|---|---|---|
IL-1ra | ||||
Pre-treatment | 13 | 903.30 (420.37, 4591.80) | ||
6 hrs after treatment | 12 | 2981.15 (505.29, 42000) | ||
DIFFERENCE | 12 | 1902.16 (−60.67, 38854.80) |
2.6 (0.95, 32.3) | 0.0024* |
IP-10 | ||||
Pre-treatment | 13 | 210.60 (71.44, 1017.52) | ||
6 hrs after treatment | 12 | 1129.79 (176.12, 5164.90) | ||
DIFFERENCE | 12 | 856.84 (34.53, 4810.08) | 4.9 (1.1, 21.5) | 0.0005* |
IL -1α, IL -1β, IL - 1ra, IL -2, IL -4, IL - 5, IL - 6, IL -8, IL -10, IL -17, ENA −78/CXCL5, FGF -basic, G-CSF, GM -CSF, IFN -γ, MCP -1/CCL2 ,MIP -lα,/CCL3 MIP -lβ/CCL4 , RANTE S/CCL5 , TNF - α, Tpo, YEGF , sCD40L, IL -12p70, IL -7, IL -12p40, IL -13, IL -15 and IP -10/CXCL10 were analyzed. The table represents the cytokines that were significantly different between pre and 6 hours post 852A dose 1.