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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Mol Oncol. 2014 Jun 24;8(8):1575–1587. doi: 10.1016/j.molonc.2014.06.009

Fig. 5. BUD31 peptide potently suppresses AR-mediated function and growth of AR-harboring prostate cancer cells, and blocks AR N-C interactions.

Fig. 5

Short peptides of wt-BUD31, C320 (FxxLY motif), 3–18 (FxxLF motif) (Hsu et al., 2003), and 3-14 (LxxLL motif) peptides conjugated with TAT were synthesized and tested in LNCaP cells (B and C) and PC-3 cells (D) in the presence and absence of 0.2 nM DHT. (A) Peptide sequences. (B-D) Test peptides suppress AR transactivation in the presence of DHT or HF (B), suppress LNCaP cell growth in vitro (C), and block AR N-C interactions (D).