TABLE 1.

Relative Frequency of Clinical Conditions in Untreated HIV Infection (from Simpkins et al, Pediatrics in Review, 2009) [46]

Body System or Illness Category*	Specific Conditions	Relative Frequency
		Common	Uncommon
Infections: recurrent, severe, or unusual (opportunistic)	Recurrent or chronic otitis, sinusitis	C
	Recurrent or severe pneumonia	C
	Recurrent or severe bacteremia	C
	Opportunistic infections, such as PCP, MAC, invasive candidal infections	C
Lymphoreticular system	Generalized lymphadenopathy	C
	Hepatomegaly	C
	Splenomegaly	C
	Parotid enlargement	C
	Lymphoid interstitial pneumonitis	C
Growth	Failure to thrive	C
	Weight loss, wasting	C
	Stunting	C
	Delayed puberty	C
Neurologic	Neurodevelopmental delay or regression	C
	Abnormal tone (increased or decreased)	C
	Gait disturbance	C
	Peripheral neuropathy		U
	Stroke		U
Pulmonary	Bacterial pneumonia	C
	Lymphoid interstitial pneumonitis	C
	Bronchiectasis		U
	Pneumothorax		U
Cardiovascular	Cardiomyopathy		U
	Pericardial effusion		U
	Conduction abnormalities		U
	Hypertension		U
	Vasculopathy		U
Gastrointestinal	Gastritis	C
	Duodenitis	C
	Hepatitis		U
	Pancreatitis		U
	Cholecystitis		U
	Diarrhea	C
	Gastrointestinal bleeding		U
	Abdominal pain	C
Renal	Proteinuria	C
	Renal tubular acidosis		U
	Renal failure		U
	Hypertension		U
Hematologic	Anemia	C
	Neutropenia	C
	Thrombocytopenia	C
Dermatologic	Seborrhea	C
	Eczema	C
	Urticaria		U
	Zoster	C
	Herpes simplex infections	C
	Tinea corporis, capitis, unguium	C
	Bacterial infections	C
	Molluscum contagiosum	C
	Warts (HPV)	C
Genital/Reproductive	HPV-related dysplasia (cervical, anal)	C
	Pelvic inflammatory disease	C
	Delayed puberty	C

^*Some conditions belong to more than one category. HPV=human papillomavirus, MAC=Mycobacterium avium complex, PCP=Pneumocystis jiroveci pneumonia