Table 2.
Serum Clinical Chemistry of Wildtype (WT), Pept1 Knockout (KO), and Humanized PEPT1 (huPEPT1) Micea
| WT | Pept1 KO | huPEPT1 | |
|---|---|---|---|
| Body Weight | |||
| male, 7–8 weeks (g) | 21.5 ± 0.6 (12) | 21.3 ± 0.6 (12) | 22.1 ± 0.5 (12) |
| female, 7–8 weeks (g) | 17.9 ± 0.3 (12) | 17.7 ± 0.4 (12) | 18.0 ± 0.3 (12) |
| Serum | |||
| sodium (mmol/L) | 145 ± 1 (6) | 147 ± 1 (6) | 146 ± 1 (6) |
| potassium (mmol/L) | 7.3 ± 0.5 (6) | 7.4 ± 0.3 (6) | 7.7 ± 0.5 (6) |
| chloride (mmol/L) | 113 ± 1 (6) | 113 ± 1 (6) | 113 ± 1 (6) |
| calcium (mg/dL) | 9.7 ± 0.5 (6) | 9.5 ± 0.1 (6) | 9.8 ± 0.2 (6) |
| albumin (g/dL) | 3.4 ± 0.1 (6) | 3.5 ± 0.1 (6) | 3.6 ± 0.1 (6) |
| protein (g/dL) | 6.4 ± 0.1 (6) | 6.4 ± 0.1 (5) | 6.3 ± 0.1 (4) |
| creatinine (mg/dL) | 0.24 ± 0.03 (6) | 0.25 ± 0.01 (6) | 0.28 ± 0.05 (6) |
| bilirubin (mg/dL) | 0.16 ± 0.05 (5) | 0.08 ± 0.02 (5) | 0.14 ± 0.02 (5) |
| glucose (mg/dL) | 131 ± 22 (5) | 163 ± 18 (6) | 188 ± 6 (4) |
| BUN (mg/dL) | 29.5 ± 2.4 (6) | 27.5 ± 1.5 (6) | 33.3 ± 2.1 (6) |
| ALT (U/L) | 95.2 ± 16.0 (6) | 78.0 ± 4.8 (6) | 101 ± 6 (6) |
| ALP (U/L) | 186 ± 29 (6) | 94.2 ± 11.7 (6) | 149 ± 15 (6) |
| AST (U/L) | 124 ± 18 (6) | 124 ± 16 (6) | 104 ± 10 (6) |
a
Data are expressed as mean ± SE (n = number of mice). Pept1 KO (mPept1−/−) and huPEPT1 (mPept1−/−/hPEPT1+/−) mice were not significantly different than WT (mPept1+/+) mice, as evaluated by ANOVA/Dunnett’s analyses. BUN is urea nitrogen, ALT is alanine aminotransferase, ALP is alkaline phosphatase, and AST is aspartate aminotransferase.