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. Author manuscript; available in PMC: 2014 Oct 7.
Published in final edited form as: Mol Pharm. 2014 Sep 2;11(10):3737–3746. doi: 10.1021/mp500497p

Table 3.

Noncompartmental Pharmacokinetics of [14C]GlySar after a 5.0 nmol/g Oral Dose in Wildtype (WT), Pept1 Knockout (KO), and Humanized PEPT1 (huPEPT1) Micea

parameter (units) WT Pept1 KO huPEPT1
Cmax (μM) 2.71 ± 0.09 1.27 ± 0.05b 2.86 ± 0.09
Tmax (h) 0.33 ± 0.08 1.83 ± 0.17b 0.33 ± 0.08
AUC0–0.5 (μM·h) 1.12 ± 0.02 0.34 ± 0.01b 1.04 ± 0.04
AUC0–2 (μM·h) 4.76 ± 0.12 2.04 ± 0.04b 4.61 ± 0.04
AUC0–6 (μM·h) 11.6 ± 0.6 6.66 ± 0.25b 12.1 ± 0.3
a

Data are expressed as mean ± SE (n = 3).

b

***P < 0.001, as evaluated by ANOVA/Dunnett’s analyses of WT (mPept1+/+), Pept1 KO (mPept1−/−), and huPEPT1 (mPept1−/−/hPEPT1+/−) mice, where WT was the control group.