Table 3.
parameter (units) | WT | Pept1 KO | huPEPT1 |
---|---|---|---|
Cmax (μM) | 2.71 ± 0.09 | 1.27 ± 0.05b | 2.86 ± 0.09 |
Tmax (h) | 0.33 ± 0.08 | 1.83 ± 0.17b | 0.33 ± 0.08 |
AUC0–0.5 (μM·h) | 1.12 ± 0.02 | 0.34 ± 0.01b | 1.04 ± 0.04 |
AUC0–2 (μM·h) | 4.76 ± 0.12 | 2.04 ± 0.04b | 4.61 ± 0.04 |
AUC0–6 (μM·h) | 11.6 ± 0.6 | 6.66 ± 0.25b | 12.1 ± 0.3 |
Data are expressed as mean ± SE (n = 3).
***P < 0.001, as evaluated by ANOVA/Dunnett’s analyses of WT (mPept1+/+), Pept1 KO (mPept1−/−), and huPEPT1 (mPept1−/−/hPEPT1+/−) mice, where WT was the control group.