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. Author manuscript; available in PMC: 2014 Dec 16.
Published in final edited form as: Nat Commun. 2014 Nov 21;5:5383. doi: 10.1038/ncomms6383

Figure 10. Model for NEAT1 function in prostate cancer.

Figure 10

Functional ERĪ± signaling in prostate cancer modulates expression of lncRNA NEAT1. Prostate epithelial cells positive for NEAT1 have oncogenic advantage and are refractile to androgen inhibitors or androgen ablation therapy. NEAT1 a histone interacting lncRNA and transcriptional regulator, is recruited to promoters of several prostate cancer specific genes. NEAT1 can modulate epigenetic landscape of target promoters and maintains expression of AR dependent and independent genes. Selection of alternate nuclear receptor signaling is a novel hallmark of prostate cancer progression.