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A catalytic scheme proposed for the reduction and oxidation of retinal(ol) by the SDR domain of WWOX. The arrows indicate the direction of flow of a pair of electrons (2e−). Additionally, both the reductive and oxidative reactions are facilitated by virtue of the ability of Y293/K297 catalytic dyad, located within the RXXXK active site motif of WWOX, to mediate acid/base catalysis.
