Skip to main content
. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Nat Commun. 2014 Nov 11;5:5209. doi: 10.1038/ncomms6209

Figure 2. Trans-synaptic RPTPσ:TrkC complex crystal structure.

Figure 2

(a) TrkCTK- (non-catalytic isoform) domain organization. LRR, leucine-rich repeat region (N, N-terminal cysteine-rich region; 1–3, leucine-rich repeats; C, C-terminal cysteine-rich region). Putative N-linked glycosylation sites, lollipops; filled lollipops remain in LRRIg1cryst construct. (b) Space-filled and tube representations of chicken RPTPσ Ig1–2:TrkC LRRIg1cryst crystal structure. N-linked glycans in atom representation. Disordered RPTPσ Lys-loop, blue dotted line; TrkC LRRIg1cryst amino-acid residue 62–78 junction, asterisk. (c–e) Detailed view of bonding interactions at RPTPσ:TrkC interface for binding sites 1–3. Corresponding electron density is illustrated in Supplementary Fig. 7. Potential electrostatic and hydrogen bonds, black dashed lines; oxygen atoms, red; nitrogen atoms, bluewhite.