Table 1.
Patient | Sex | Age (years) | Diagnosis | Previous treatment | Past adjuvant CT | Cycles | Reason for enrollment | KPS at start of TMZ 3/11 | Diagnosis to start of TMZ 3/11 (months) | |
---|---|---|---|---|---|---|---|---|---|---|
Surgery | Radiotherapy | |||||||||
1 | F | 61 | GBM | STR | IMRT + TMZ | TMZ 5/23 | 2 | Stable disease, patients choice | 90 | 7 |
2 | F | 35 | GBM | B | IMRT + TMZ | TMZ 5/23 | 6 | MRI disease progression | 90 | 7 |
3 | M | 55 | GBM | B | IMRT + TMZ | TMZ 5/23 | 1 | Clinical progression | 80 | 7 |
4 | M | 55 | GBM | B | IMRT | TMZ 5/23 | 7 | MRI disease progression | 60 | 8 |
5 | M | 56 | GBM | GTR | IMRT + TMZ | TMZ 5/23 | 11 | MRI disease progression | 80 | 11 |
6 | M | 57 | GBM | B | IMRT + TMZ | None | – | Clinical progression | 70 | 4 |
7 | M | 36 | AA | B | IMRT + TMZ | TMZ 5/23 | 2 | MRI disease progression | 80 | 5 |
8 | M | 33 | APXA | GTR | IMRT + TMZ | TMZ 5/23 | 3 | MRI disease progression | 80 | 12 |
9 | M | 33 | GBM | B | IMRT | TMZ 5/23 | 12 | MRI disease progression | 80 | 16 |
10 | M | 49 | GBM | STR | IMRT + TMZ | TMZ 5/23 | 2 | MRI disease progression | 90 | 7 |
11 | M | 53 | GBM | B | IMRT + TMZ | TMZ 5/23 | 3 | MRI disease progression | 70 | 8 |
12 | M | 73 | GBM | GTR | IMRT + TMZ | TMZ 5/23 | 3 | MRI disease progression | 90 | 6 |
13 | M | 63 | GBM | GTR | IMRT + TMZ | TMZ 5/23 | 4 | MRI disease progression | 90 | 10 |
14 | M | 58 | GBM | STR | IMRT + TMZ | None | – | MRI disease progression | 80 | 3† |
15 | F | 56 | GBM | STR | IMRT + TMZ | TMZ 5/23 | 3 | MRI disease progression | 70 | 7 |
Fluorodeoxyglucose-PET-positive recurrent disease.
AA: Anaplastic astrocytoma; APXA: Anaplastic pleomorphic xanthoastrocytoma; B: Biopsy; CT: Chemotherapy; F: Female; GBM: Glioblastoma; GTR: Gross total resection; IMRT: Intensity modulated radiation therapy; KPS: Karnofsky performance status; M: Male; STR: Subtotal resection; TMZ: Temozolomide.