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. Author manuscript; available in PMC: 2014 Nov 5.
Published in final edited form as: Am J Clin Exp Urol. 2014 Apr;2(1):45–56.

Table 1.

Metastatic step-specific anti-cancer therapeutics

Target Drug Company Metastatic steps targeted Reference
MMP Marimastat (BB-2516) British Biotech Extravasation Trial NCT00003010 (Metastatic breast cancer)
Thrombin Tinzaparin Ottawa Hospital Research Institute Survival in the circulation Extravasation Trial NCT01455831 (Metastatic colon cancer)
Src AZD0530 AstraZeneca Secondary tumor formation Extravasation Trial NCT01144481 (Risk factors for skeletal related events in breast cancer)
EGFR Herceptin (trastuzumab) GlaxoSmithKline Secondary tumor formation Trial NCT01064349 (Breast cancer metastasis to the brain)
VEGFR Dovitinib Novartis Extravasation Secondary tumor formation Trial NCT01262027 (Metastatic inflammatory breast cancer)
α5β1 Volociximab Abbott Extravasation Secondary tumor formation Trial NCT00100685 (Metastatic renal cell carcinoma)