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Off-target expression of transgenic hAADC protein
| Brain structure | AAV2-hAADC Low dose | AAV2-hAADC High dose |
|---|---|---|
|
| ||
| Globus pallidus | F | F |
|
| ||
| Thalamus | F/Ca | F/Ca |
|
| ||
| Medial forebrain bundle | - | F |
|
| ||
| Subthalamic nucleus | F/Ca | F/Ca |
|
| ||
| Substantia nigra pars reticulata | F | F |
|
| ||
| Red nucleus | F/C | F/C |
|
| ||
| Spinal cord | - | F |
|
| ||
| Other | F | F |
| Corona radiata/IC Area dorsal to SN | Corona radiata/IC Area dorsal to SN | |
Surrounding cannula tract. Abbreviations: C: cells; F: fibers; IC: internal capsule.
