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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Toxicol Rep. 2014 Jan 1;1:820–833. doi: 10.1016/j.toxrep.2014.09.010

Figure 1. Release of PCB126 and PCB153 from polymeric implants in vitro and in vivo.

Figure 1

A, structures and polymeric implants of PCB126 and PCB153. B, daily and cumulative release of PCB153 from polymeric implants in vitro. C and D, Cumulative release of PCB126 (C) and PCB153 (D) from polymeric implants (one 1.5 cm × 2.6 mm dia; 0.15 and 5% loads, respectively) grafted subcutaneously into female S/D rats. Animals were euthanized after 6, 15 and 45 d; recovered implants were solvent extracted to measure the residual PCBs spectrophotometrically against a standard curve; data represent an average of three implants ± SD. Average daily dose over 45 d: 0.98 and 48.6 μg of PCB126 and PCB153, respectively. Release at 15 and 45 days was compared with 6 day release. **p < 0.01, ***p < 0.001