Skip to main content
. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Oncogene. 2014 Dec 22;34(36):4683–4691. doi: 10.1038/onc.2014.422

Figure 1.

Figure 1

From metabolism to epigenetic remodeling. (A) SIRT1 activity depends on the NAD+/NADH ratio modulated by glycolysis while OGT uses GlcNAc produced by the hexosamine pathway. Pyruvate entering the TCA cycle produces αKG, a critical cofactor for JHDM and TET. Acetyl-CoA is converted from the citrate generated by the TCA cycle and used as a donor by HAT. Finally, the increase in ATP/ADP ratio from the TCA cycle also inactivates AMPK. (B) SAM acts as a methyl donor for HMT and TET and is obtained through the coordinate action of the folate and methionine cycles, termed one-carbon metabolism.