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. Author manuscript; available in PMC: 2015 May 21.
Published in final edited form as: Kidney Int. 2015 Jan 7;87(5):930–939. doi: 10.1038/ki.2014.373

Figure 3. Worsened glomerulonephritis in CfH-/- mice with CfH-/- and CD11b-/- bone marrow.

Figure 3

CfH-/- mice chimeric for wildtype (WT), CfH-/-, FcγR-/-, and CD11b-/- bone marrow were actively immunized with apoferritin to induce chronic serum sickness, or saline as control. (a) After five weeks, BUN was measured. Data from individual mice are shown. These data from each group were normally distributed (Anderson-Darling test P > 0.04), while the population means were unequal (one-way ANOVA, P < 0.001). The Tukey all-pairwise approach was used to compare individual means. *P < 0.007 vs. all other groups. (b) Representative histopathology is shown. Diffuse endocapillary proliferative glomerulonephritis was evident in all groups receiving apoferritin. The white arrow shows periglomerular infiltrates in CD11b-/- chimeras. Semiquantitative scores for GN are provided as median, with Q3-Q1 interval in parentheses. Group medians were significantly different (P = 0.003, Mood Median test). *P < 0.05 vs. all other groups.