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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Nat Commun. 2015 Jan 12;6:5829. doi: 10.1038/ncomms6829

Figure 2. Global view of DNA binding and transcriptional regulation in MTB.

Figure 2

A) Plot of binding distribution in 1kb nucleotide window (−500 to +500) surrounding CDS or transcription start sites. ROC/AUC analysis indicated that the optimal promoter window size is −150 to + 70 nucleotides (indicated by vertical dashed lines and shading of histogram). Binding events correlated with 1.5-fold induction or repression in the over-expression dataset24 are depicted in red and green, respectively. B) The relationship between the number of binding events detected vs. the number of transcriptional changes associated with induction of each TF in this study. Rv0494 (orange triangle) is an example of a TF with prolific binding but limited differential gene expression. Additional genes discussed in text highlighted in yellow with symbols as follows: Rv1657/ArgR (downward triangle), Rv1846v/BlaI (square), Rv3133c/DosR (octagon), Rv3849/EspR (diamond).