Table 1.

Proteomic of Annexin A2/Atg16L⁺ vesicles

Atg16L/Annexin A2+ vesicles	Function	Reference
Actin	Vesicle trafficking
Microtubule-actin cross-linking factor 1	Vesicle trafficking
Twinfilin	Modulator of Actin polymerization
WAS/WASL interacting protein (WIPF1)	Modulator of Actin polymerization
Coronin-1	Autophagosome formation	42
Cortactin	Autophagosome-lysosomal fusion	43
Dynactin	Autophagosome movement	44
Cofilin 1	Modulator of Actin polymerization
AP-2 (beta and mu subunits)	Atg16L interaction	7
Clathrin	Atg16L interaction	7
Synaptotagmin II	Endocytosis
Synaptojanin 2	PI(4,5)P2 hydrolysis
Endophilin A3	Endocytosis; Vesicular transport
Annexin A2	Lipid segregation (PS and PIs)
Protein S100A11	Annexin A2 binding partner
ASAP2	ARF6 regulator
Vesicle-fusing ATPase	Vesicle trafficking
ARF6	PIP2 formation via PIP5K; PLD Inhibition	6
Girdin	Autophagy regulator	30
VAMP 7	SNARE	7
VAMP 3	SNARE	5
VtiB	SNARE	7
Ubiquitin	Binding to Atg16L	45
Galectin 3	Endocytosis
Aurora Kinase	Autophagy regulators	31
Vps 13c	Endocytosis; Regulation PI phosphates
Hrb	VAMP 7 adaptor	7

Proteins highlighted in bold were previously reported to be associated with MA