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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: FEBS Lett. 2013 Mar 13;587(8):1180–1188. doi: 10.1016/j.febslet.2013.03.002

Figure 2. Cap-dependent translation initiation and classes of IRES-mediated initiation.

Figure 2

(A) Schematic of canonical cap-dependent initiation [102] and viral IRES classes. (B) Model of HCV IRES initiation. The pseudoknot at the base of domain III mimics a tRNA [51] and may position the AUG in the ribosome active site. (C) Simplified model of the c-myc IRES element. The ribosome entry site is adjacent to an RNA pseudoknot [102].