Table 1.

MIC data of antibiotics (μg/mL) against drug resistant bacterial strains. Comparison of efficacy of 10 and vancomycin against a panel of methicillin-resistant S. aureus (MRSA) and glycopeptide intermediate S. aureus (GISA), and multi-drug resistant (MDR) S. pneumonia, comparison of efficacy of 10 and commercial antibiotics against a panel of vancomycin resistant S. aureus (VRSA) from the Network of Antimicrobial Resistance in S. aureus (NARSA), and comparison of efficacy of 10 and rifampicin against multi-drug resistance M. tuberculosis H37RV and TT372 strains. The 7H9 medium contains OADC (oleic acid, albumin, dextrose and catalase), which is needed for the growth of the bacteria. GAS medium has a final pH of 6.6 and the Proskauer and Beck (P&B) medium has a final pH of 7.4.

Compound	S. aureus MRSA clinical isolate	S. aureus MRSA ATCC 43300	S. aureus GISA NRS 17	S. aureus MRSA DapRSA clinical isolate	S. aureus GISA, MRSA NRS 1	S. pneum MDR ATCC 700677
Vancomycin	1	1	4	2	4	1
Compound 10	8	8	4	4	4	4

Compound	S. aureus NARSA VRS 3b	S. aureus NARSA VRS 4	S. aureus NARSA VRS 1	S. aureus NARSA VRS 10
Vancomycin	64	> 64	>64	>64
Teicoplanin	4	32	>64	64
Daptomycin	1	2	4	4
Dalbavancin	1	16	>64	>64
Telavancin	0.5	1	2	4
Compound 10	4	4	4	4

Compound	M. Tuberculosis H37Rv			M. Tuberculosis TT372
	GAS medium	P&B medium	7H9 medium	7H9 medium
Rifampicin	<0.002	<0.002	<40	<40
Compound 10	20	20	160	160