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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Med Chem. 2014 Dec 4;57(24):10314–10328. doi: 10.1021/jm500902x

Figure 1.

Figure 1

(A) Structure and data for sulfonylpyrrolidine-derived probe 1, ML232. (B) Structure and data for hit quinazolinedione 2 with highlighted regions of structure–activity relationship optimization.