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. Author manuscript; available in PMC: 2015 Jan 26.
Published in final edited form as: Psychopharmacology (Berl). 2014 Aug 15;232(3):605–621. doi: 10.1007/s00213-014-3704-1

Fig. 5.

Fig. 5

Effect of chronic (21 day) daily administration of haloperidol, risperidone, aripiprazole, or ITI-007 on striatal dopamine metabolism in vivo. Mice (N= 6/dosing group) received an oral dose of vehicle (5 % gum arabic in water, 6.7 ml/kg volume, p.o.) or vehicle solution containing either haloperidol (1 or 3 mg/kg), risperidone (1 or 10 mg/kg), aripiprazole (3 or 30 mg/kg), or ITI-007 (1, 3, or 10 mg/kg) once daily for 21 days. Animals were killed by focused cranial microwave irradiation 2 h after the last drug dose. Striatum was collected for analysis of levels of dopamine and dopamine metabolites, DOPAC and HVA, using HPLC-EC. DOPAC/DA ratio, used as an index of dopamine synthetic rate, is shown. *p<0.05 compared with vehicle alone; #p<0.05 compared with ITI-007 (3); ^p<0.05 compared with ITI-007 (10)