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. Author manuscript; available in PMC: 2015 Oct 5.
Published in final edited form as: Cancer Sci. 2015 Mar 3;106(4):421–429. doi: 10.1111/cas.12610

Figure 1. Designed PI polyamide structure and binding site.

Figure 1

Structures and binding sites for synthesized PI polyamides A, Myc-5; B, FITC labeled Myc-5 C, Mismatch PI polyamide. Base sequence specificity depends on side-by-side pairing of Pyrrole and Imidazole amino acids in the minor groove of DNA. Black and white circles, Im and Py rings, respectively; curved line, hairpin junction,; β is β-alanine; Dp is diaminomethylene propylamide and W=A or T.